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FULL WRITEUP: SR9009 (Stenabolic)

Chemical Name: Ethyl 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]pyrrolidine-1-carboxylate
Other Name(s): Stenabolic
Half-Life: 24 hours

SR9009, also known as Stenabolic, is a selective androgen receptor modulator (SARM) being referred to as ‘exercise in a bottle’. Initial trials on mice showed an increase in muscle and metabolic rate without exercise, and enhanced stamina with exercise. Essentially, SR9009 has shown promise to improve endurance and metabolism to become leaner.

SR9009 was first developed by Professor Thomas Burris from The Scripps Research Institute. Initial findings were published in the journal Nature Medicine in 2012, with studies showing that Stenabolic significantly increases exercise endurance in animal models. [1]

The compound affects the core biological clock, synchronizing the body’s circadian rhythm with the 24-hour cycle of day and night.

How SR-9009 Works

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The compound SR9009 works by binding to one of the body’s naturally occurring molecules, called Rev-Erbα. This molecule influences lipid and glucose metabolism in the liver, the production of fat-storing cells, and the response of macrophages (cells that remove dead or dying cells) during inflammation.

The study showed that mice lacking Rev-Erbα had decreased muscle metabolic activity and running capacity. However, Burris’ group demonstrated that activation of Rev-Erbα using Stenabolic led to increased metabolic activity in skeletal muscle in both culture and mice. The difference was a 50% increase in running capacity for mice treated with SR9009 – even when exercise was restricted.


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Professor Burris explained that the study resulted in animals developing muscles just like an athlete who has been training, even when they haven’t. He believes that Rev-Erbα affects muscle cells through the creation of new mitochondria, and the removal of defective mitochondria via macrophages.

Basically, SR-9009 is one of the strongest endurance boosters out there. It is often compared to GW-5051516 (Cardarine) because the benefits are comparable.

Benefits of SR9009

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There are 7 primary benefits of SR9009 that have been observed in both initial studies and user-reported reviews.

  1. SR9009 increases weight loss

Stenabolic shows great promise in increasing weight loss, even without exercise – which is why it’s being touted as “exercise in a bottle”.

In initial studies, researchers chose mice with low skeletal muscle and metabolism to treat with SR9009. Over a 30-day study, the muscle and metabolic rate of the mice increased, even when they weren’t allowed to exercise.

Increased mitochondria activity was noted in muscle, as well as an increase in macrophages – cells that remove dying or dead cells – enhancing the energy output of the animal’s muscles to create athletic, oxidative muscle without any actual exercise.

Due to this increase in muscle activity, SR9009 helped the body burn calories instead of turning them into fat, effectively allowing an increase in weight loss.

  1. SR9009 increases stamina and endurance

Additional to muscle conditioning, initial studies showed that once the mice that were treated with Stenabolic for 30 days were allowed to exercise, they showed a 50% increase in endurance – running longer and covering more distance than controls. [1]

This may be due to an increase in the glucose oxidation in skeletal muscle, allowing the body to go faster for longer with a higher level of strength and stamina.

According to Burris:

The animals actually get muscles like an athlete who has been training. The pattern of gene expression after treatment with SR9009 is that of an oxidative-type muscle— again, just like an athlete.”

  1. SR9009 may lower blood cholesterol

Mice treated with SR9009 for 7-10 days showed reduced blood levels of triglycerides and total cholesterol. [1]

Another study [2] suggested that targeting Rev-Erbα may be an effective method for suppressing LDL cholesterol levels using SR9009. Over an 8-week period, genetically modified mice with a similar fat profile to humans were treated with SR9009, resulting in a significant decrease in total cholesterol, triglycerides, and LDL cholesterol.

  1. SR9009 indicates a decrease in inflammation

Stimulation of Rev-Erbα activity by SR9009 was shown to greatly diminish ventilator-induced lung edema and inflammatory cells in rats. [3]

The study suggests that the circadian rhythm affects the immune response, which may exacerbate inflammation. As Rev-Erbα plays a role in regulating the circadian rhythm, SR9009 may help reduce inflammation by activating Rev-Erbα.

  1. SR9009 may increase wakefulness

 Due to its ability to activate Rev-Erbα, Stenabolic can affect the wakefulness of mice. As it affects the circadian rhythm, when SR9009 was injected into mice during periods they usually sleep, they were kept awake longer and had less REM sleep.

However, when the mice were injected with SR9009 during their normal awake hours, there was no perceptible change in their behavior.

This suggests that Stenabolic may be useful for sleep-related disorders such as narcolepsy or shift workers.

  1. SR9009 may reduce heart disease

Studies show that both normal and genetically modified older mice had improved heart function when injected with SR9009. Mice with surgically-induced heart growth (hypertrophy) showed a reduction in heart size and weight without affecting their blood pressure after two weeks of treatment with SR9009.

  1. SR9009 may effectively reduce anxiety

Mice injected with SR9009 twice per day for 3 to 10 days showed decreased anxiety-like behavior. Interestingly, it has been suggested that SR9009 was as effective as a benzodiazepine, even though it shows the potential to increase stamina and endurance of athletes.

SR-9009 Dosage Guidelines

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The best SR9009 dosage should be roughly 30 to 40mg per day for a 10-12 week cycle.

Due to the short 4 hour half-life of SR9009, it is recommended to spread the dose across 3-4 times per day.

If you’re taking 40mg of SR9009 per day, this means that you will have to take 10mg every 4 hours. This is essential, the drug needs to be stable within your body to produce the best results.

What’s also great about SR9009 is it can used by both male and females. You can reference the chart on SR9009 Dosages for your convenience:

SR9009 SARMs Dosage Table

Men
30-40mg per day

Women
30-40mg per day

Also, when you complete one cycle, make sure you take a 4 week break and take proper PCT.

Side Effects of SR 9009 (Stenabolic)

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Stenabolic does not work as a fat burner, thyroid accelerator or appetite suppressant – yet still allows an increase in weight and fat loss.

There has also been no suppression of natural testosterone shown, and it is suggested not to be liver toxic.

However, as there have not been any human clinical trials, we still don’t know long-term indications or side effects of taking SR9009.

Buy SR9009 (Stenabolic) Online

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SR9009 can no longer be bought from US-based companies due to the recent ban. Powersupps UK is the best alternative for you to go for.

If you want to use SR9009 your next cycle and are ready to buy it online, you can purchase it right here at Powersupps UK.

To try some for yourself, you can browse our collection when you’re ready to buy SR9009 supplements online.

Recommended product: SR9009 STENABOLIC by Evolved Research

Conclusion

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Although few studies have been done on SR9009, the buzz in the bodybuilding industry suggests that this SARM has taken the athletic world by storm. User reviews show that there appear to be more pros than cons, with minimal side effects reported, replaced by amazing results.

Because it does not affect testosterone suppression and primarily works to stimulate Rev-Erbα activity, Stenabolic is a great addition for both men and women looking to increase their strength, stamina and fat loss. There is also no indication that SR9009 is liver toxic, unlike a lot of the other stuff out there. You can always purchase a cycle support product if you want to play it safe.

The only obvious concern with SR9009 is the limited clinical human studies that have been performed in the scientific community. However, anecdotal testimonials suggest that side effects are minimal. Use SR9009 at your own risk, and if you do experience any side effects make sure to immediately discontinue use.

If you’re looking for increased endurance, stamina, fat loss and strength, SR9009 is a great choice for your next cycle.

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FAQs

Clinical trials have not been performed on humans, and SR9009 is not FDA approved for human use. However, user-reported reviews are promising, and side effects look to be minimal if not non-existent.

The primary benefits of taking SR9009 are cutting and fat burning, and it would be almost pointless to try to bulk while taking Stenabolic. We suggest leaving your SR9009 cycle for cutting.

Some users report seeing results after 2-3 weeks, with near effortless fat loss after that point.

Most user-reported reviews suggest taking SR9009 for 8-12 weeks before taking a miniPCT of 4 weeks. However, some users suggest it can be taken for up to 16 weeks before cycling off.

Yes! Many women report using SR9009 as part of their stack to increase endurance and cut body fat.

The suggested dosage is 30-40mg per day for both men and women, although trialing different doses to find your sweet spot is recommended.

Because SR9009 does not affect hormone levels, a full PCT is not necessary. However, many users strongly suggest taking a miniPCT for 4 weeks to ensure their hormone levels are back to normal after an 8-12 week SARM cycle.

Yes. Due to it’s short half life, SR9009 is best taken in split doses 3-4 times per day.

Yes, SR9009 is legal to purchase from a number of research companies for research purposes. It is not yet sold for human consumption.

No, SR9009 is not a steroid and will not affect sexual tissue in the same way that anabolic steroids, such as testosterone, do. SR9009 works more in the way of a ligand by stimulating Rev-Erbα activity to boost mitochondria production and remove dead or dying cells.

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References

[1] “Drug Candidate Leads To Improved Endurance.” Scripps.edu. N.p., 2018. Web. 10 May 2018.
https://www.scripps.edu/newsandviews/e_20130729/burris.html

[2] Sitaula S, et al. “Rev-Erb Regulation Of Cholesterologenesis. – Pubmed – NCBI.” Ncbi.nlm.nih.gov. N.p., 2018. Web. 10 May 2018.
https://www.ncbi.nlm.nih.gov/pubmed/28213272

[3] “Drug Candidate Leads To Improved Endurance.” Scripps.edu. N.p., 2018. Web. 10 May 2018.
https://www.ncbi.nlm.nih.gov/pubmed/24355794

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